Prevention Of Decline in Cognition After Stroke Trial
PODCAST (ISRCTN85562386)
The 'Prevention Of Decline in Cognition After Stroke Trial' (PODCAST) is a collaborative, international, multicentre, prospective, randomised, blinded endpoint, partial-factorial, parallel-group, controlled trial designed to test the safety and efficacy of (i) intensive versus guideline blood pressure lowering, and (ii) intensive versus guideline lipid lowering in patients with recent (3-7 months) ischaemic stroke or primary intracerebral haemorrhage
600+ patients will be enrolled 3-7 months after stroke and treatment will be given for up to 8 years. The primary outcome is Addenbrooks Cognitive Examination (ACE, which includes MMSE) and will be determined during and at end of trial by observers blinded to treatment. Initially, a start-up phase, funded jointly by The Stroke Association and Alzheimer's Society, in 600 patients in the UK will test safety, feasibility and tolerability.
PODCAST trial
Enter PODCAST trial web-site
Status
As of 29 February 2012:
Enrolled patients: 22 with 10 (46%) in lipid lowering arm (see logon page for the very latest figure)
Centres who have recruited one or more patients: 7 in UK
Funding
Forthcoming events
PODCAST will be present at:
News
- October 2010: First participant recruited, Nottingham
- September 2010: First UK Investigator meeting held, Nottingham. Trial Steering Committee meeting also held.
- September 2009: ISRCTN number issued: ISRCTN85562386
- September 2009: Trial Steering Committee meeting at The Stroke Association, London
- January 2009: Start-up phase of PODCAST trial funded jointly by TSA and AS.
Documents
Expression of interest form, version 1.0 (pdf file)
Expression of interest form, version 1.0 (doc file)
Further documents are here
Newsletters
Newsletter 03, February 2012 (pdf file)
Newsletter 02, October 2012 (pdf file)
Newsletter 01, June 2011 (pdf file)
Presentations/publications/listings/media
Demo/practice website and database
Demo / practice website
Study personnel
Trial Steering Committee:
- Independent experts: John O'Brien (TSC Chair, Newcastle), Stephen Ball (Cardiology, Leeds), one more member to be appointed
- Grant holders: Philip Bath (Stroke/Chief Investigator - lipid lowering arm, Nottingham), Gary Ford (Stroke/Chief Investigator - BP lowering arm, Newcastle), Clive Ballard (Psychiatry, London), Alistair Burns (Pychiatry, Manchester), Jonathan Mant (Public Health, Cambridge), Peter Passmore (Geriatrics, Belfast), John Reckless (Lipids, Bath), Rob Stewart (Psychiatry, London), Joanna Wardlaw (Neuroradiology, Edinburgh)
- Patient & Carer representatives: Dave Hanbury, John Murray, Andrew Pepper
- Funders' representative: Susanne Sorensen (Alzheimer's Society)
- Sponsor representative: Angela Shone (University of Nottingham)
Trial Management Committee (Nottingham):
Philip Bath (Chair), Lynn Stokes (Trial Coordinator), Sandeep Ankolekar (Medic), Cheryl Hogg (Statistician), Wim Clarke (Finance), Valerie Chandrakumar (Secretary)
Independent Data Monitoring Committee:
Chair - to be appointed, Jan Staessen (Leuven), Chris Weir (Glasgow, Statistician), one more member to be appointed
Cognition/Dementia Adjudicators:
Alistair Burns (Chair, Manchester), Clive Ballard (London), Gary Ford (Newcastle)
Vascular Events Adjudicators:
Peter Passmore (Chair, Belfast), Amit Mistri (Leicester), Bob Wilcox (Nottingham)
Serious Adverse Event Adjudicator:
Niki Sprigg (Nottingham)
Neuroimaging:
Joanna Wardlaw (Chair, Edinburgh), other members to be appointed
Health economics:
Paul McCrone, Martin Knapp (London)
Programming/database management:
Graham Watson, Liz Walker (Nottingham)
Contact details
PODCAST Trial Office
Division of Stroke Medicine
Institute of Neuroscience
University of Nottingham
Clinical Sciences Building
City Hospital campus
Hucknall Road
Nottingham NG5 1PB
UK
Telephone: +44 (0)115 823 1770
Fax: +44 (0)115 823 0273
E-mail: podcast@nottingham.ac.uk
Written by Philip Bath, last updated 29 February 2012
